Is there a case for adding Progesterone in Menopausal Hormone Therapy for Women without a Uterus?
Are there any benefits of adding a progestogen to estrogen if a woman does not have a uterus?
Women without a uterus would typically not be prescribed a progestogen since they technically don't need it to protect the lining of the uterus. But the symptoms of menopause are not solely because of the lack of estrogen.
Progesterone stimulates the brain to produce a calming neurotransmitter called GABA. One of the functions of GABA is to calm the brain, which may help women relax and switch off the brain and that can help women sleep much better. Since it has a calming effect, progesterone may also reduce anxiety and panic attacks for those women who continue to face these symptoms despite being on estrogen replacement and without any other underlying cause. In addition to that progesterone also has a positive impact on bone health.
Bottomline, yes there are benefits to adding Progesterone to estrogen for women without a uterus.
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